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Although the etiology and pathophysiology of INOCA and HFpEF are complex and not fully understood, there is no doubt that the underlying cause of both conditions is endothelial dysfunction (ED) which further promotes the development of left ventricular diastolic dysfunction (LVDD).Diastolic dysfunction is a problem with diastole, the first part of your heartbeat. Typically, your lower heart chambers relax and fill with blood during diastole. Diastolic dysfunction occurs when your lower heart chambers don’t relax as they should. Over time, the dysfunction can lead to diastolic heart failure.
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